Immunomodulatory

Zinc has been widely shown to have significant antioxidant activity, especially as a cofactor for the zinc-dependent enzyme superoxide dismutase (ZnSOD), responsible for neutralizing excessively produced free radicals in an organism. In other words, it has an important action as an antioxidant. It is also a fundamental element as a regulator of the immune response since it is known to play a key role in the normal activity of neutrophils and "natural killer" (NK) cells. It also influences the functions of T lymphocytes and B lymphocytes.

Zinc is an important trace mineral that people need to stay healthy. It is well known that it is an essential trace element in cellular metabolism, important in protein synthesis and in the composition of metabolic enzymes.

Manganese is a mineral found in various foods including nuts, legumes, seeds, tea, whole grains, and green leafy vegetables. It is considered an essential nutrient, because it is required for the normal functioning of the body.

The antioxidant properties of manganese and its activity as a catalyst for the manganese-dependent enzyme superoxide dismutase (MnSOD) are well known, a matter for which it is an important element in the protection processes against oxidative damage. This enzyme, together with catalase, has an important role in controlling this damage. Manganese is also an essential component of energy producing and detoxifying enzymes. It is also involved in the formation of connective tissue, bones, and nerve function. It is also applied to the skin to heal wounds. It is also an essential nutrient that participates in many chemical processes in the body, including the processing of cholesterol, carbohydrates and proteins.

Selenium is essential as an antioxidant and as an immunomodulator. It is an essential trace mineral that the body has to obtain to produce special proteins, called antioxidant enzymes. These participate in the prevention of cell damage.

It is a crucial element in the constitution of selenoproteins that are essential enzymes to counteract oxidative stress. In this way, it has an important action as an antioxidant, contributing to the protection of DNA against oxidative damage. There is evidence of its use in supplementation, particularly in respiratory diseases. Scientific works support its use in acute respiratory infections, predominantly in pneumonia. Zn and Se deficiency is common in children in developing countries due to the high incidence of malnutrition. The administration of Zn and the decrease in the incidence of these respiratory infections is shown. Additionally, selenium can help prevent certain cancers and protect the body from the toxic effects of heavy metals and other harmful substances.